Drug interactions
Lorlatinib + Vincristine
Severity: Moderate
Lorlatinib and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A4 and may lower vincristine exposure, since vincristine is a CYP3A4 and P-gp substrate. This could reduce efficacy, though the effect is not well documented.
What this interaction means in plain words
Lorlatinib and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Vincristine belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4 and possibly P-gp, increasing vincristine clearance.
What to do
Monitor for reduced response to vincristine; consider an alternative to lorlatinib if the combination is essential for curative therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Vincristine?
MediHelp rates the interaction as moderate. Lorlatinib and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib induces CYP3A4 and may lower vincristine exposure, since vincristine is a CYP3A4 and P-gp substrate. This could reduce efficacy, though the effect is not well documented.
How serious is the interaction between Lorlatinib and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to vincristine; consider an alternative to lorlatinib if the combination is essential for curative therapy.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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