Drug interactions
Lorlatinib + Zuranolone
Severity: Moderate
Lorlatinib and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone is cleared primarily by CYP3A4, and lorlatinib induces this enzyme. Reduced zuranolone exposure may lessen its antidepressant effect.
What this interaction means in plain words
Lorlatinib and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Zuranolone belongs to Central Nervous System.
Why it happens
Lorlatinib induces CYP3A4 and increases zuranolone metabolism.
What to do
Monitor the antidepressant response during the 14-day course. Consider an alternative to lorlatinib or a different antidepressant strategy if efficacy appears reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Lorlatinib with Zuranolone?
MediHelp rates the interaction as moderate. Lorlatinib and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone is cleared primarily by CYP3A4, and lorlatinib induces this enzyme. Reduced zuranolone exposure may lessen its antidepressant effect.
How serious is the interaction between Lorlatinib and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the antidepressant response during the 14-day course. Consider an alternative to lorlatinib or a different antidepressant strategy if efficacy appears reduced.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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