Drug interactions
Lormetazepam + Maprotiline
Severity: Moderate
Lormetazepam and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lormetazepam is a benzodiazepine hypnotic and maprotiline is a sedating antidepressant. Combined use can cause additive drowsiness, impaired coordination and reduced alertness the next day.
What this interaction means in plain words
Lormetazepam and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression.
What to do
Use the lowest effective doses and advise against driving and alcohol. Monitor elderly patients for oversedation and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Lormetazepam with Maprotiline?
MediHelp rates the interaction as moderate. Lormetazepam and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lormetazepam is a benzodiazepine hypnotic and maprotiline is a sedating antidepressant. Combined use can cause additive drowsiness, impaired coordination and reduced alertness the next day.
How serious is the interaction between Lormetazepam and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and advise against driving and alcohol. Monitor elderly patients for oversedation and falls.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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