Drug interactions
Lormetazepam + Nalbuphine
Severity: Major
Lormetazepam and Nalbuphine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of nalbuphine and a benzodiazepine hypnotic produces additive sedation and may cause respiratory depression. Severe cases can lead to profound sedation, coma or death.
What this interaction means in plain words
Lormetazepam and Nalbuphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive central nervous system and respiratory depression through opioid receptor activity and enhanced GABA-A signalling.
What to do
Avoid the combination where possible; if needed, limit doses and duration. Monitor sedation level and respiratory rate closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Frequently asked questions
Can I take Lormetazepam with Nalbuphine?
MediHelp rates the interaction as major. Lormetazepam and Nalbuphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent use of nalbuphine and a benzodiazepine hypnotic produces additive sedation and may cause respiratory depression. Severe cases can lead to profound sedation, coma or death.
How serious is the interaction between Lormetazepam and Nalbuphine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if needed, limit doses and duration. Monitor sedation level and respiratory rate closely.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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