Drug interactions
Lormetazepam + Oxymorphone
Severity: Major
Lormetazepam and Oxymorphone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of an opioid and a benzodiazepine hypnotic produces additive sedation and respiratory depression, with a risk of coma and death. This is a recognized high-risk combination.
What this interaction means in plain words
Lormetazepam and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via mu-opioid agonism and GABA-A potentiation.
What to do
Avoid the combination where possible; if it is needed, limit doses and duration and monitor for sedation and slowed breathing. Warn patients not to drive and to avoid alcohol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Lormetazepam with Oxymorphone?
MediHelp rates the interaction as major. Lormetazepam and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent use of an opioid and a benzodiazepine hypnotic produces additive sedation and respiratory depression, with a risk of coma and death. This is a recognized high-risk combination.
How serious is the interaction between Lormetazepam and Oxymorphone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if it is needed, limit doses and duration and monitor for sedation and slowed breathing. Warn patients not to drive and to avoid alcohol.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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