Drug interactions
Loxapine + Scullcap
Severity: Moderate
Loxapine and Scullcap: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Skullcap has traditionally been used as a calming herb and may have sedative properties. Combined with loxapine, it could increase drowsiness and psychomotor impairment.
What this interaction means in plain words
Loxapine and Scullcap can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, probably via GABAergic activity of the herb; the evidence is limited.
What to do
Advise the patient to avoid skullcap or use it only after discussion with the prescriber. Monitor for excess sedation and caution against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Loxapine and Scullcap, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Loxapine with Scullcap?
MediHelp rates the interaction as moderate. Loxapine and Scullcap can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Skullcap has traditionally been used as a calming herb and may have sedative properties. Combined with loxapine, it could increase drowsiness and psychomotor impairment.
How serious is the interaction between Loxapine and Scullcap?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient to avoid skullcap or use it only after discussion with the prescriber. Monitor for excess sedation and caution against driving.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
