Drug interactions
Loxapine + Sufentanil sl
Severity: Major
Loxapine and Sufentanil sl: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an opioid with a sedating antipsychotic produces additive central nervous system and respiratory depression. Patients may develop profound sedation, hypotension, respiratory depression, coma or death.
What this interaction means in plain words
Loxapine and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic CNS and respiratory depression from opioid agonism plus antipsychotic sedative and hypotensive effects.
What to do
Use together only if alternatives are inadequate, with the lowest effective doses and shortest duration. Monitor closely for sedation, respiratory rate and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Loxapine with Sufentanil sl?
MediHelp rates the interaction as major. Loxapine and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid with a sedating antipsychotic produces additive central nervous system and respiratory depression. Patients may develop profound sedation, hypotension, respiratory depression, coma or death.
How serious is the interaction between Loxapine and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only if alternatives are inadequate, with the lowest effective doses and shortest duration. Monitor closely for sedation, respiratory rate and blood pressure.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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