Drug interactions
Loxapine + Yohimbine
Severity: Moderate
Loxapine and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist with stimulant and anxiogenic effects, and it may counter loxapine sedation. It can also raise blood pressure and heart rate while loxapine causes alpha-blockade, so the net effect is unpredictable.
What this interaction means in plain words
Loxapine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic effects: central alpha-2 antagonism by yohimbine versus sedative and alpha-blocking activity of loxapine.
What to do
Monitor blood pressure, heart rate, agitation and psychiatric symptoms. Avoid yohimbine in patients with psychosis or unstable cardiovascular status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Loxapine with Yohimbine?
MediHelp rates the interaction as moderate. Loxapine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist with stimulant and anxiogenic effects, and it may counter loxapine sedation. It can also raise blood pressure and heart rate while loxapine causes alpha-blockade, so the net effect is unpredictable.
How serious is the interaction between Loxapine and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, agitation and psychiatric symptoms. Avoid yohimbine in patients with psychosis or unstable cardiovascular status.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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