Drug interactions
Loxapine inhaled + Metaxalone
Severity: Moderate
Loxapine inhaled and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled loxapine is sedating and can cause bronchospasm, and metaxalone adds further central nervous system depression. The combination may produce marked drowsiness and impaired alertness.
What this interaction means in plain words
Loxapine inhaled and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression from the antipsychotic and the muscle relaxant.
What to do
Observe the patient for excessive sedation after loxapine administration and avoid driving or hazardous tasks. Reduce the metaxalone dose if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Loxapine inhaled with Metaxalone?
MediHelp rates the interaction as moderate. Loxapine inhaled and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled loxapine is sedating and can cause bronchospasm, and metaxalone adds further central nervous system depression. The combination may produce marked drowsiness and impaired alertness.
How serious is the interaction between Loxapine inhaled and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe the patient for excessive sedation after loxapine administration and avoid driving or hazardous tasks. Reduce the metaxalone dose if oversedation occurs.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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