Drug interactions
Loxapine inhaled + Oxymorphone
Severity: Moderate
Loxapine inhaled and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled loxapine can cause sedation and bronchospasm, and opioids add to CNS and respiratory depression. The combination may cause deeper sedation than either drug alone.
What this interaction means in plain words
Loxapine inhaled and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from antipsychotic receptor blockade and mu-opioid agonism.
What to do
Monitor sedation and respiratory status after loxapine administration, and have the inhaled dose given in a supervised setting. Reduce the opioid dose if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Loxapine inhaled with Oxymorphone?
MediHelp rates the interaction as moderate. Loxapine inhaled and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled loxapine can cause sedation and bronchospasm, and opioids add to CNS and respiratory depression. The combination may cause deeper sedation than either drug alone.
How serious is the interaction between Loxapine inhaled and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status after loxapine administration, and have the inhaled dose given in a supervised setting. Reduce the opioid dose if oversedation occurs.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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