Drug interactions
Lsd + Maprotiline
Severity: Moderate
Lsd and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
LSD is a serotonin receptor agonist, and antidepressants can alter its effects, with unpredictable outcomes. Combination may increase the risk of serotonin toxicity, and maprotiline also lowers the seizure threshold.
What this interaction means in plain words
Lsd and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Serotonergic receptor agonism by LSD with additive monoaminergic effects of maprotiline.
What to do
Advise against use of LSD with the antidepressant. Manage any serotonin toxicity symptomatically and seek urgent care for severe agitation, hyperthermia or seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Lsd with Maprotiline?
MediHelp rates the interaction as moderate. Lsd and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. LSD is a serotonin receptor agonist, and antidepressants can alter its effects, with unpredictable outcomes. Combination may increase the risk of serotonin toxicity, and maprotiline also lowers the seizure threshold.
How serious is the interaction between Lsd and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against use of LSD with the antidepressant. Manage any serotonin toxicity symptomatically and seek urgent care for severe agitation, hyperthermia or seizures.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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