Drug interactions
Lsd + Sertraline
Severity: Moderate
Lsd and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
LSD acts as a serotonin receptor agonist, and SSRIs generally blunt its effects through receptor downregulation, though serotonin toxicity has been theorized and unpredictable reactions are reported. Evidence is limited and mostly anecdotal.
What this interaction means in plain words
Lsd and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing and additive serotonergic effects at 5-HT2A receptors and synaptic serotonin; mechanism not fully established.
What to do
Advise against using LSD with sertraline. Monitor for serotonin syndrome and manage supportively if exposure occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Lsd with Sertraline?
MediHelp rates the interaction as moderate. Lsd and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. LSD acts as a serotonin receptor agonist, and SSRIs generally blunt its effects through receptor downregulation, though serotonin toxicity has been theorized and unpredictable reactions are reported. Evidence is limited and mostly anecdotal.
How serious is the interaction between Lsd and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against using LSD with sertraline. Monitor for serotonin syndrome and manage supportively if exposure occurs.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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