Drug interactions
Lsd + Sumatriptan
Severity: Moderate
Lsd and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
LSD is a potent serotonin receptor agonist, and combining it with a triptan may add serotonergic stimulation and increase the risk of serotonin toxicity. Data are limited to theoretical considerations and sparse reports.
What this interaction means in plain words
Lsd and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic receptor agonism.
What to do
Advise against recreational LSD use during triptan therapy. Monitor for hyperthermia, agitation, clonus and autonomic instability if exposure occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Lsd with Sumatriptan?
MediHelp rates the interaction as moderate. Lsd and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. LSD is a potent serotonin receptor agonist, and combining it with a triptan may add serotonergic stimulation and increase the risk of serotonin toxicity. Data are limited to theoretical considerations and sparse reports.
How serious is the interaction between Lsd and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against recreational LSD use during triptan therapy. Monitor for hyperthermia, agitation, clonus and autonomic instability if exposure occurs.
What other medicines interact with Sumatriptan?
MediHelp also lists interactions of Sumatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Sumatriptan page.
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