Drug interactions
Lsd + Tranylcypromine
Severity: Major
Lsd and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
LSD is a potent serotonergic agonist, and MAO inhibition may intensify and prolong its effects and increase the risk of serotonin toxicity, hypertension and hyperthermia. Unpredictable psychiatric reactions are also possible.
What this interaction means in plain words
Lsd and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic effects from 5-HT receptor agonism by LSD and increased serotonin availability from MAO inhibition.
What to do
Advise patients to avoid LSD while taking tranylcypromine. Treat suspected serotonin toxicity with supportive care and monitoring of vital signs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Lsd with Tranylcypromine?
MediHelp rates the interaction as major. Lsd and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. LSD is a potent serotonergic agonist, and MAO inhibition may intensify and prolong its effects and increase the risk of serotonin toxicity, hypertension and hyperthermia. Unpredictable psychiatric reactions are also possible.
How serious is the interaction between Lsd and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid LSD while taking tranylcypromine. Treat suspected serotonin toxicity with supportive care and monitoring of vital signs.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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