Drug interactions
Lumacaftor / ivacaftor + Nicardipine
Severity: Minor
Lumacaftor / ivacaftor and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor is a CYP3A substrate, but lumacaftor induces CYP3A, offsetting the effect of inhibitors at steady state. Nicardipine is also a weak inhibitor, so a clinically relevant rise in ivacaftor exposure is unlikely.
What this interaction means in plain words
Lumacaftor / ivacaftor and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by nicardipine is largely offset by lumacaftor-mediated CYP3A induction.
What to do
No dose adjustment is needed. Monitor for ivacaftor adverse effects and blood pressure, since lumacaftor induction may also lower nicardipine levels.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Lumacaftor / ivacaftor with Nicardipine?
MediHelp rates the interaction as minor. Lumacaftor / ivacaftor and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor is a CYP3A substrate, but lumacaftor induces CYP3A, offsetting the effect of inhibitors at steady state. Nicardipine is also a weak inhibitor, so a clinically relevant rise in ivacaftor exposure is unlikely.
How serious is the interaction between Lumacaftor / ivacaftor and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for ivacaftor adverse effects and blood pressure, since lumacaftor induction may also lower nicardipine levels.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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