Drug interactions
Lumacaftor / ivacaftor + Prednisone
Severity: Moderate
Lumacaftor / ivacaftor and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is a strong CYP3A inducer and may lower prednisolone exposure, reducing anti-inflammatory effect. Loss of control of the underlying condition could occur.
What this interaction means in plain words
Lumacaftor / ivacaftor and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumacaftor induces CYP3A, increasing metabolism of prednisolone.
What to do
Monitor clinical response and increase the prednisone dose if the effect is inadequate. Reduce the dose again if lumacaftor/ivacaftor is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Lumacaftor / ivacaftor with Prednisone?
MediHelp rates the interaction as moderate. Lumacaftor / ivacaftor and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is a strong CYP3A inducer and may lower prednisolone exposure, reducing anti-inflammatory effect. Loss of control of the underlying condition could occur.
How serious is the interaction between Lumacaftor / ivacaftor and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase the prednisone dose if the effect is inadequate. Reduce the dose again if lumacaftor/ivacaftor is stopped.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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