Drug interactions
Lumacaftor / ivacaftor + Sertraline
Severity: Moderate
Lumacaftor / ivacaftor and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is a strong CYP3A inducer and may also induce other enzymes involved in sertraline metabolism, which could lower sertraline exposure. Ivacaftor may weakly inhibit some pathways, so the overall effect may be reduced antidepressant efficacy.
What this interaction means in plain words
Lumacaftor / ivacaftor and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 and possibly CYP2C19 by lumacaftor increases sertraline clearance.
What to do
Monitor for loss of antidepressant effect and increase the sertraline dose if clinically required. Reassess the dose if lumacaftor/ivacaftor is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Lumacaftor / ivacaftor with Sertraline?
MediHelp rates the interaction as moderate. Lumacaftor / ivacaftor and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is a strong CYP3A inducer and may also induce other enzymes involved in sertraline metabolism, which could lower sertraline exposure. Ivacaftor may weakly inhibit some pathways, so the overall effect may be reduced antidepressant efficacy.
How serious is the interaction between Lumacaftor / ivacaftor and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antidepressant effect and increase the sertraline dose if clinically required. Reassess the dose if lumacaftor/ivacaftor is stopped.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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