Drug interactions
Lumacaftor / ivacaftor + Tinidazole
Severity: Moderate
Lumacaftor / ivacaftor and Tinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is a strong CYP3A inducer and may speed the metabolism of tinidazole. This could lower tinidazole concentrations and reduce its effectiveness against infections such as giardiasis, amebiasis or trichomoniasis.
What this interaction means in plain words
Lumacaftor / ivacaftor and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumacaftor induces CYP3A4, increasing the clearance of tinidazole.
What to do
Monitor for treatment failure and consider a higher-dose or alternative regimen if the response is inadequate. Reassess the need for tinidazole if the infection persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Frequently asked questions
Can I take Lumacaftor / ivacaftor with Tinidazole?
MediHelp rates the interaction as moderate. Lumacaftor / ivacaftor and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is a strong CYP3A inducer and may speed the metabolism of tinidazole. This could lower tinidazole concentrations and reduce its effectiveness against infections such as giardiasis, amebiasis or trichomoniasis.
How serious is the interaction between Lumacaftor / ivacaftor and Tinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for treatment failure and consider a higher-dose or alternative regimen if the response is inadequate. Reassess the need for tinidazole if the infection persists.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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