Drug interactions
Lumacaftor / ivacaftor + Tolazamide
Severity: Moderate
Lumacaftor / ivacaftor and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is an enzyme inducer and may lower exposure to CYP2C9-metabolized drugs. Tolazamide's glucose-lowering effect could be reduced, leading to worsened glycemic control.
What this interaction means in plain words
Lumacaftor / ivacaftor and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumacaftor induces CYP2C9 and other enzymes, increasing sulfonylurea metabolism.
What to do
Monitor blood glucose and HbA1c after starting or stopping lumacaftor/ivacaftor. Increase the tolazamide dose or switch agent if control deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Lumacaftor / ivacaftor with Tolazamide?
MediHelp rates the interaction as moderate. Lumacaftor / ivacaftor and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is an enzyme inducer and may lower exposure to CYP2C9-metabolized drugs. Tolazamide's glucose-lowering effect could be reduced, leading to worsened glycemic control.
How serious is the interaction between Lumacaftor / ivacaftor and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or stopping lumacaftor/ivacaftor. Increase the tolazamide dose or switch agent if control deteriorates.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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