Drug interactions
Lumateperone + Netupitant-palonosetron
Severity: Moderate
Lumateperone and Netupitant-palonosetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Netupitant may increase lumateperone exposure, increasing sedation, orthostatic hypotension and other adverse effects.
What this interaction means in plain words
Lumateperone and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lumateperone belongs to Central Nervous System; Netupitant-palonosetron belongs to Gastrointestinal Tract.
Why it happens
Netupitant inhibits CYP3A4, reducing lumateperone clearance.
What to do
Reduce lumateperone to 21 mg daily while a moderate CYP3A4 inhibitor is used. Monitor for sedation and hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Lumateperone
Frequently asked questions
Can I take Lumateperone with Netupitant-palonosetron?
MediHelp rates the interaction as moderate. Lumateperone and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Netupitant may increase lumateperone exposure, increasing sedation, orthostatic hypotension and other adverse effects.
How serious is the interaction between Lumateperone and Netupitant-palonosetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce lumateperone to 21 mg daily while a moderate CYP3A4 inhibitor is used. Monitor for sedation and hypotension.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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