Drug interactions
Lumefantrine + Mexiletine
Severity: Moderate
Lumefantrine and Mexiletine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine inhibits CYP2D6, a pathway for mexiletine metabolism, so mexiletine levels may increase. Mexiletine has a narrow therapeutic index and toxicity includes tremor, dizziness and arrhythmia.
What this interaction means in plain words
Lumefantrine and Mexiletine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumefantrine inhibits CYP2D6-mediated mexiletine metabolism.
What to do
Monitor for mexiletine toxicity and ECG changes during lumefantrine treatment and reduce the dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Frequently asked questions
Can I take Lumefantrine with Mexiletine?
MediHelp rates the interaction as moderate. Lumefantrine and Mexiletine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine inhibits CYP2D6, a pathway for mexiletine metabolism, so mexiletine levels may increase. Mexiletine has a narrow therapeutic index and toxicity includes tremor, dizziness and arrhythmia.
How serious is the interaction between Lumefantrine and Mexiletine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mexiletine toxicity and ECG changes during lumefantrine treatment and reduce the dose if symptoms occur.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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