Drug interactions
Lumefantrine + Nebivolol
Severity: Moderate
Lumefantrine and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine inhibits CYP2D6, the main pathway for nebivolol clearance, potentially raising nebivolol levels and causing bradycardia or hypotension. Lumefantrine's QT-prolonging effect adds cardiac concern.
What this interaction means in plain words
Lumefantrine and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2D6-mediated nebivolol metabolism by lumefantrine.
What to do
Monitor heart rate and blood pressure during treatment and reduce the nebivolol dose if needed. Check ECG if other QT-prolonging risks exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Lumefantrine with Nebivolol?
MediHelp rates the interaction as moderate. Lumefantrine and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine inhibits CYP2D6, the main pathway for nebivolol clearance, potentially raising nebivolol levels and causing bradycardia or hypotension. Lumefantrine's QT-prolonging effect adds cardiac concern.
How serious is the interaction between Lumefantrine and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure during treatment and reduce the nebivolol dose if needed. Check ECG if other QT-prolonging risks exist.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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