Drug interactions
Lumefantrine + Nicardipine
Severity: Minor
Lumefantrine and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is a CYP3A4 substrate and has not been shown to be a clinically relevant inducer, so a meaningful fall in nicardipine levels is not expected. Nicardipine may mildly increase lumefantrine exposure, and lumefantrine prolongs the QT interval, but nicardipine is not known to add QT risk.
What this interaction means in plain words
Lumefantrine and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism for reduced nicardipine effect; any change would reflect minor CYP3A4 competition.
What to do
No routine adjustment is needed. Monitor blood pressure and treatment response during the antimalarial course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Lumefantrine with Nicardipine?
MediHelp rates the interaction as minor. Lumefantrine and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine is a CYP3A4 substrate and has not been shown to be a clinically relevant inducer, so a meaningful fall in nicardipine levels is not expected. Nicardipine may mildly increase lumefantrine exposure, and lumefantrine prolongs the QT interval, but nicardipine is not known to add QT risk.
How serious is the interaction between Lumefantrine and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor blood pressure and treatment response during the antimalarial course.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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