Drug interactions
Lumefantrine + Nimodipine
Severity: Minor
Lumefantrine and Nimodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is not a well-established CYP3A4 inducer, and the expected effect on nimodipine is minimal. Any change in nimodipine exposure is likely small.
What this interaction means in plain words
Lumefantrine and Nimodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 induction; the mechanism is not firmly established.
What to do
No routine adjustment is needed. Monitor blood pressure and response if used together.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Frequently asked questions
Can I take Lumefantrine with Nimodipine?
MediHelp rates the interaction as minor. Lumefantrine and Nimodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine is not a well-established CYP3A4 inducer, and the expected effect on nimodipine is minimal. Any change in nimodipine exposure is likely small.
How serious is the interaction between Lumefantrine and Nimodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor blood pressure and response if used together.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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