Drug interactions
Lumefantrine + Paclitaxel
Severity: Minor
Lumefantrine and Paclitaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine may weakly induce CYP3A4, which could slightly lower paclitaxel exposure. The clinical relevance is unclear and likely minimal given short antimalarial courses.
What this interaction means in plain words
Lumefantrine and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 induction increasing paclitaxel metabolism; evidence is limited.
What to do
No adjustment is generally needed; monitor clinical response to paclitaxel.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paclitaxel
Frequently asked questions
Can I take Lumefantrine with Paclitaxel?
MediHelp rates the interaction as minor. Lumefantrine and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine may weakly induce CYP3A4, which could slightly lower paclitaxel exposure. The clinical relevance is unclear and likely minimal given short antimalarial courses.
How serious is the interaction between Lumefantrine and Paclitaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is generally needed; monitor clinical response to paclitaxel.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporin. The full list is on the Paclitaxel page.
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