Drug interactions
Lumefantrine + Prednisone
Severity: Minor
Lumefantrine and Prednisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine has no established ability to alter prednisolone exposure meaningfully, and no clinically significant interaction is documented. Lumefantrine is a CYP3A4 substrate but not a notable inducer or inhibitor.
What this interaction means in plain words
Lumefantrine and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Both are CYP3A4 substrates; no established clinically relevant effect on each other.
What to do
No dose adjustment is needed. Monitor antimalarial efficacy as usual in patients on prolonged high-dose steroids.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Lumefantrine with Prednisone?
MediHelp rates the interaction as minor. Lumefantrine and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine has no established ability to alter prednisolone exposure meaningfully, and no clinically significant interaction is documented. Lumefantrine is a CYP3A4 substrate but not a notable inducer or inhibitor.
How serious is the interaction between Lumefantrine and Prednisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor antimalarial efficacy as usual in patients on prolonged high-dose steroids.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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