Drug interactions
Lumefantrine + Vardenafil
Severity: Moderate
Lumefantrine and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is a weak CYP3A4 inducer, which could lower vardenafil exposure and reduce its efficacy. Lumefantrine also prolongs the QT interval, as does vardenafil, so cardiac effects may add up.
What this interaction means in plain words
Lumefantrine and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Weak CYP3A4 induction by lumefantrine and additive QT prolongation.
What to do
Monitor for reduced erectile response and ECG changes in patients with QT risk factors. Avoid combining where other QT-prolonging drugs are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Frequently asked questions
Can I take Lumefantrine with Vardenafil?
MediHelp rates the interaction as moderate. Lumefantrine and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine is a weak CYP3A4 inducer, which could lower vardenafil exposure and reduce its efficacy. Lumefantrine also prolongs the QT interval, as does vardenafil, so cardiac effects may add up.
How serious is the interaction between Lumefantrine and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced erectile response and ECG changes in patients with QT risk factors. Avoid combining where other QT-prolonging drugs are present.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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