Drug interactions
Lumefantrine + Vinblastine
Severity: Minor
Lumefantrine and Vinblastine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is not a recognized clinically important CYP3A4 inducer, and any lowering of vinblastine exposure is not established. The interaction is theoretical.
What this interaction means in plain words
Lumefantrine and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No well-established mechanism; weak CYP3A4 induction has been postulated.
What to do
No specific action is needed beyond monitoring treatment response. Check the short antimalarial course for other interactions.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lumefantrine and Vinblastine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Vinblastine
Frequently asked questions
Can I take Lumefantrine with Vinblastine?
MediHelp rates the interaction as minor. Lumefantrine and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine is not a recognized clinically important CYP3A4 inducer, and any lowering of vinblastine exposure is not established. The interaction is theoretical.
How serious is the interaction between Lumefantrine and Vinblastine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond monitoring treatment response. Check the short antimalarial course for other interactions.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
