Drug interactions
Lurbinectedin + Metronidazole
Severity: Moderate
Lurbinectedin and Metronidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurbinectedin is a CYP3A4 substrate, and inhibitors can raise exposure and increase myelosuppression and hepatotoxicity. Metronidazole is a weak inhibitor, so the effect is expected to be limited.
What this interaction means in plain words
Lurbinectedin and Metronidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurbinectedin belongs to Oncology; Metronidazole belongs to Anti Parasitic.
Why it happens
Possible weak CYP3A4 inhibition by metronidazole reducing lurbinectedin clearance.
What to do
Monitor blood counts and liver enzymes closely during co-treatment. Prefer a non-interacting antimicrobial if one is clinically suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Lurbinectedin
Frequently asked questions
Can I take Lurbinectedin with Metronidazole?
MediHelp rates the interaction as moderate. Lurbinectedin and Metronidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurbinectedin is a CYP3A4 substrate, and inhibitors can raise exposure and increase myelosuppression and hepatotoxicity. Metronidazole is a weak inhibitor, so the effect is expected to be limited.
How serious is the interaction between Lurbinectedin and Metronidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and liver enzymes closely during co-treatment. Prefer a non-interacting antimicrobial if one is clinically suitable.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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