Drug interactions
Lurbinectedin + Phenytoin
Severity: Major
Lurbinectedin and Phenytoin: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin may lower lurbinectedin concentrations and reduce its antitumor activity. Strong CYP3A inducers are not recommended with lurbinectedin.
What this interaction means in plain words
Lurbinectedin and Phenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lurbinectedin belongs to Oncology; Phenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces CYP3A4, accelerating lurbinectedin metabolism.
What to do
Avoid the combination and use a non-inducing antiseizure drug. If unavoidable, monitor tumor response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Lurbinectedin
Frequently asked questions
Can I take Lurbinectedin with Phenytoin?
MediHelp rates the interaction as major. Lurbinectedin and Phenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenytoin may lower lurbinectedin concentrations and reduce its antitumor activity. Strong CYP3A inducers are not recommended with lurbinectedin.
How serious is the interaction between Lurbinectedin and Phenytoin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing antiseizure drug. If unavoidable, monitor tumor response.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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