Drug interactions
Macitentan + Oxcarbazepine
Severity: Moderate
Macitentan and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may reduce macitentan and its active metabolite exposure through CYP3A4 induction. Strong inducers like rifampin markedly reduce exposure, and weaker inducers may have a smaller effect. Efficacy in pulmonary arterial hypertension could decline.
What this interaction means in plain words
Macitentan and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macitentan belongs to Cardiovascular; Oxcarbazepine belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases macitentan metabolism.
What to do
Monitor functional class and symptoms, and consider a non-inducing anticonvulsant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Macitentan
- Amiodarone + Macitentan Major
- Apalutamide + Macitentan Major
- Bosentan + Macitentan Major
- Carbamazepine + Macitentan Major
- Clarithromycin + Macitentan Major
- Efavirenz + Macitentan Major
Frequently asked questions
Can I take Macitentan with Oxcarbazepine?
MediHelp rates the interaction as moderate. Macitentan and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may reduce macitentan and its active metabolite exposure through CYP3A4 induction. Strong inducers like rifampin markedly reduce exposure, and weaker inducers may have a smaller effect. Efficacy in pulmonary arterial hypertension could decline.
How serious is the interaction between Macitentan and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor functional class and symptoms, and consider a non-inducing anticonvulsant.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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