Drug interactions
Magnesium + Mycophenolic acid
Severity: Moderate
Magnesium and Mycophenolic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium-containing antacids lower mycophenolic acid exposure, which may weaken immunosuppression and increase the chance of graft rejection.
What this interaction means in plain words
Magnesium and Mycophenolic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium belongs to Gastrointestinal Tract; Mycophenolic acid belongs to Miscellaneous.
Why it happens
Cation binding or reduced absorption of mycophenolate in the gut.
What to do
Give magnesium products at least 2 hours apart from mycophenolic acid. Monitor graft function if antacid use is regular.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolic acid
Other interactions of Magnesium
- Ciprofloxacin + Magnesium Major
- Magnesium + Pancuronium Major
- Magnesium + Rocuronium Major
- Magnesium + Vecuronium Major
- Amikacin + Magnesium Moderate
- Amphotericin b deoxycholate + Magnesium Moderate
Frequently asked questions
Can I take Magnesium with Mycophenolic acid?
MediHelp rates the interaction as moderate. Magnesium and Mycophenolic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium-containing antacids lower mycophenolic acid exposure, which may weaken immunosuppression and increase the chance of graft rejection.
How serious is the interaction between Magnesium and Mycophenolic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give magnesium products at least 2 hours apart from mycophenolic acid. Monitor graft function if antacid use is regular.
What other medicines interact with Mycophenolic acid?
MediHelp also lists interactions of Mycophenolic acid with, for example, Activated charcoal, Azathioprine, Cholestyramine. The full list is on the Mycophenolic acid page.
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