Drug interactions
Magnesium supplement + Nicardipine
Severity: Moderate
Magnesium supplement and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium has calcium-antagonist and vasodilating properties, so it can add to the blood pressure lowering of nicardipine. Calcium channel blockers have also been reported to enhance neuromuscular blockade and hypotension with parenteral magnesium, as used in obstetrics. Oral supplements pose a lower risk.
What this interaction means in plain words
Magnesium supplement and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive calcium channel antagonism and vasodilation, with potential potentiation of neuromuscular blockade.
What to do
With intravenous magnesium, monitor blood pressure, heart rate, reflexes and respiratory function closely. With oral supplements, monitor blood pressure and adjust the nicardipine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Magnesium supplement with Nicardipine?
MediHelp rates the interaction as moderate. Magnesium supplement and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium has calcium-antagonist and vasodilating properties, so it can add to the blood pressure lowering of nicardipine. Calcium channel blockers have also been reported to enhance neuromuscular blockade and hypotension with parenteral magnesium, as used in obstetrics. Oral supplements pose a lower risk.
How serious is the interaction between Magnesium supplement and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With intravenous magnesium, monitor blood pressure, heart rate, reflexes and respiratory function closely. With oral supplements, monitor blood pressure and adjust the nicardipine dose if needed.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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