Drug interactions
Magnesium supplement + Verapamil
Severity: Moderate
Magnesium supplement and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium has calcium-antagonist activity, so with verapamil it can cause additive hypotension and neuromuscular blockade. The risk is highest with parenteral magnesium and less with oral supplements.
What this interaction means in plain words
Magnesium supplement and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive calcium antagonism and vasodilation.
What to do
Monitor blood pressure and heart rate, and for muscle weakness with high or intravenous magnesium doses. Adjust the doses if hypotension or weakness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Magnesium supplement with Verapamil?
MediHelp rates the interaction as moderate. Magnesium supplement and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium has calcium-antagonist activity, so with verapamil it can cause additive hypotension and neuromuscular blockade. The risk is highest with parenteral magnesium and less with oral supplements.
How serious is the interaction between Magnesium supplement and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and for muscle weakness with high or intravenous magnesium doses. Adjust the doses if hypotension or weakness occurs.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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