Drug interactions
Maitake + Tolbutamide
Severity: Minor
Maitake and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maitake mushroom extracts lowered glucose in animal studies. With tolbutamide, an additive hypoglycemic effect is theoretically possible, but human data are lacking.
What this interaction means in plain words
Maitake and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive glucose lowering through improved insulin sensitivity, based on animal data.
What to do
Monitor blood glucose if maitake supplements are used with tolbutamide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Maitake with Tolbutamide?
MediHelp rates the interaction as minor. Maitake and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maitake mushroom extracts lowered glucose in animal studies. With tolbutamide, an additive hypoglycemic effect is theoretically possible, but human data are lacking.
How serious is the interaction between Maitake and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if maitake supplements are used with tolbutamide.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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