Drug interactions
Maprotiline + Meclizine
Severity: Moderate
Maprotiline and Meclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclizine is a sedating antihistamine with anticholinergic properties, and maprotiline adds to these effects. The combination can cause drowsiness and anticholinergic symptoms such as dry mouth, constipation, blurred vision and urinary retention.
What this interaction means in plain words
Maprotiline and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Meclizine belongs to Respiratory.
Why it happens
Additive antimuscarinic and H1 antihistaminic CNS effects.
What to do
Counsel about drowsiness and avoid driving until response is known. Monitor older patients for confusion and urinary retention, and reduce the meclizine dose if effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Meclizine
Frequently asked questions
Can I take Maprotiline with Meclizine?
MediHelp rates the interaction as moderate. Maprotiline and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclizine is a sedating antihistamine with anticholinergic properties, and maprotiline adds to these effects. The combination can cause drowsiness and anticholinergic symptoms such as dry mouth, constipation, blurred vision and urinary retention.
How serious is the interaction between Maprotiline and Meclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel about drowsiness and avoid driving until response is known. Monitor older patients for confusion and urinary retention, and reduce the meclizine dose if effects appear.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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