Drug interactions
Maprotiline + Meprobamate
Severity: Moderate
Maprotiline and Meprobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meprobamate is a sedative anxiolytic and maprotiline has sedative properties. Together they may cause additive drowsiness, impaired psychomotor performance and respiratory depression in overdose.
What this interaction means in plain words
Maprotiline and Meprobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression.
What to do
Use the lowest effective doses and counsel patients about alcohol and driving. Monitor older patients closely for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Meprobamate?
MediHelp rates the interaction as moderate. Maprotiline and Meprobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meprobamate is a sedative anxiolytic and maprotiline has sedative properties. Together they may cause additive drowsiness, impaired psychomotor performance and respiratory depression in overdose.
How serious is the interaction between Maprotiline and Meprobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel patients about alcohol and driving. Monitor older patients closely for oversedation.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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