Drug interactions
Maprotiline + Mestranol
Severity: Minor
Maprotiline and Mestranol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens may alter the response to tricyclic-type antidepressants, with reports of higher antidepressant levels and more adverse effects, while other reports suggest reduced effect. Data for maprotiline specifically are limited.
What this interaction means in plain words
Maprotiline and Mestranol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Not firmly established; estrogens may affect hepatic metabolism of tricyclic antidepressants.
What to do
Monitor for sedation, anticholinergic effects and changes in antidepressant response when starting or stopping the estrogen-containing product. Adjust the maprotiline dose to clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Mestranol?
MediHelp rates the interaction as minor. Maprotiline and Mestranol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens may alter the response to tricyclic-type antidepressants, with reports of higher antidepressant levels and more adverse effects, while other reports suggest reduced effect. Data for maprotiline specifically are limited.
How serious is the interaction between Maprotiline and Mestranol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, anticholinergic effects and changes in antidepressant response when starting or stopping the estrogen-containing product. Adjust the maprotiline dose to clinical response.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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