Drug interactions
Maprotiline + Metaproterenol
Severity: Moderate
Maprotiline and Metaproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antidepressants that block norepinephrine reuptake may enhance the cardiovascular effects of beta-agonists, leading to tachycardia, palpitations and arrhythmias. Metaproterenol is a less selective beta-agonist, so cardiac effects may be more prominent.
What this interaction means in plain words
Maprotiline and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enhanced adrenergic cardiovascular response and additive effects on heart rate.
What to do
Use the lowest effective metaproterenol dose and monitor heart rate, rhythm and blood pressure. Consider a more selective beta-agonist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Metaproterenol?
MediHelp rates the interaction as moderate. Maprotiline and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antidepressants that block norepinephrine reuptake may enhance the cardiovascular effects of beta-agonists, leading to tachycardia, palpitations and arrhythmias. Metaproterenol is a less selective beta-agonist, so cardiac effects may be more prominent.
How serious is the interaction between Maprotiline and Metaproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective metaproterenol dose and monitor heart rate, rhythm and blood pressure. Consider a more selective beta-agonist.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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