Drug interactions
Maprotiline + Metformin-sitagliptin
Severity: Minor
Maprotiline and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline, a tetracyclic antidepressant, may alter glycemic control and hypoglycemia awareness in some patients. The effect is small and inconsistent.
What this interaction means in plain words
Maprotiline and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Maprotiline belongs to Central Nervous System; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Possible additive glucose-lowering effect; the mechanism is not well established.
What to do
No routine adjustment is needed; monitor blood glucose when maprotiline is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Maprotiline and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maprotiline, a tetracyclic antidepressant, may alter glycemic control and hypoglycemia awareness in some patients. The effect is small and inconsistent.
How serious is the interaction between Maprotiline and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood glucose when maprotiline is started or stopped.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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