Drug interactions
Maprotiline + Metformin
Severity: Minor
Maprotiline and Metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline may modestly alter glucose control, and a small additive glucose-lowering effect with antidiabetic drugs has been proposed. Metformin rarely causes hypoglycemia on its own, so clinical relevance is very limited.
What this interaction means in plain words
Maprotiline and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Maprotiline belongs to Central Nervous System; Metformin belongs to Endocrine.
Why it happens
Possible additive pharmacodynamic effect on glucose homeostasis; the mechanism is not firmly established.
What to do
Check glucose control periodically when maprotiline is started or stopped; no routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Metformin
Frequently asked questions
Can I take Maprotiline with Metformin?
MediHelp rates the interaction as minor. Maprotiline and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maprotiline may modestly alter glucose control, and a small additive glucose-lowering effect with antidiabetic drugs has been proposed. Metformin rarely causes hypoglycemia on its own, so clinical relevance is very limited.
How serious is the interaction between Maprotiline and Metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check glucose control periodically when maprotiline is started or stopped; no routine dose change is needed.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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