Drug interactions
Maprotiline + Metoclopramide intranasal
Severity: Moderate
Maprotiline and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause central nervous system effects. Metoclopramide may cause extrapyramidal reactions, and antidepressants that affect monoamines may add to these effects or worsen them. Combined use may increase the risk of movement disorders and neuroleptic malignant syndrome-like or serotonergic reactions.
What this interaction means in plain words
Maprotiline and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central dopaminergic antagonism (metoclopramide) with monoaminergic modulation by maprotiline; the exact mechanism is not fully established.
What to do
Monitor for extrapyramidal symptoms, restlessness, agitation and serotonergic signs. Consider an alternative antiemetic if movement disorders occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Maprotiline and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause central nervous system effects. Metoclopramide may cause extrapyramidal reactions, and antidepressants that affect monoamines may add to these effects or worsen them. Combined use may increase the risk of movement disorders and neuroleptic malignant syndrome-like or serotonergic reactions.
How serious is the interaction between Maprotiline and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, restlessness, agitation and serotonergic signs. Consider an alternative antiemetic if movement disorders occur.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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