Drug interactions
Maprotiline + Midazolam intranasal
Severity: Major
Maprotiline and Midazolam intranasal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam is a potent sedative, and sedating antidepressants can add to its CNS and respiratory depressant effects. This can produce deeper or prolonged sedation, hypoventilation or apnea.
What this interaction means in plain words
Maprotiline and Midazolam intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via GABA-A potentiation and the sedating effects of maprotiline.
What to do
Use the lowest effective midazolam dose and monitor respiration and oxygen saturation continuously. Ensure airway support and reversal capability are available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Midazolam intranasal?
MediHelp rates the interaction as major. Maprotiline and Midazolam intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Midazolam is a potent sedative, and sedating antidepressants can add to its CNS and respiratory depressant effects. This can produce deeper or prolonged sedation, hypoventilation or apnea.
How serious is the interaction between Maprotiline and Midazolam intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective midazolam dose and monitor respiration and oxygen saturation continuously. Ensure airway support and reversal capability are available.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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