Drug interactions
Maprotiline + Mobocertinib
Severity: Major
Maprotiline and Mobocertinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, and the combination increases the risk of torsades de pointes and other ventricular arrhythmias. Mobocertinib carries a labeled warning for QT prolongation.
What this interaction means in plain words
Maprotiline and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive prolongation of cardiac repolarization through blockade of cardiac potassium channels.
What to do
Avoid if possible and choose an alternative antidepressant. If unavoidable, monitor ECG and electrolytes (potassium, magnesium) more frequently and reduce the mobocertinib dose as labeled.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Mobocertinib?
MediHelp rates the interaction as major. Maprotiline and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QTc interval, and the combination increases the risk of torsades de pointes and other ventricular arrhythmias. Mobocertinib carries a labeled warning for QT prolongation.
How serious is the interaction between Maprotiline and Mobocertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and choose an alternative antidepressant. If unavoidable, monitor ECG and electrolytes (potassium, magnesium) more frequently and reduce the mobocertinib dose as labeled.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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