Drug interactions
Maprotiline + Norepinephrine
Severity: Major
Maprotiline and Norepinephrine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline blocks norepinephrine reuptake, which can markedly potentiate the pressor and arrhythmogenic effects of infused norepinephrine. This may cause severe hypertension and cardiac arrhythmias.
What this interaction means in plain words
Maprotiline and Norepinephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of norepinephrine reuptake into adrenergic neurons increases synaptic norepinephrine and enhances the response to exogenous norepinephrine.
What to do
If norepinephrine is required, start at a low dose and titrate carefully with continuous blood pressure and ECG monitoring. Be prepared to reduce the infusion rate promptly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Norepinephrine?
MediHelp rates the interaction as major. Maprotiline and Norepinephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Maprotiline blocks norepinephrine reuptake, which can markedly potentiate the pressor and arrhythmogenic effects of infused norepinephrine. This may cause severe hypertension and cardiac arrhythmias.
How serious is the interaction between Maprotiline and Norepinephrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If norepinephrine is required, start at a low dose and titrate carefully with continuous blood pressure and ECG monitoring. Be prepared to reduce the infusion rate promptly.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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