Drug interactions
Maprotiline + Octreotide
Severity: Moderate
Maprotiline and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and QT prolongation, and maprotiline, a tetracyclic antidepressant, can also prolong the QT interval. Together they may increase the risk of arrhythmia, especially with bradycardia or electrolyte disturbance.
What this interaction means in plain words
Maprotiline and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Octreotide belongs to Endocrine.
Why it happens
Additive effects on cardiac repolarization, with octreotide-related bradycardia further predisposing to QT-related arrhythmia.
What to do
Obtain a baseline ECG and monitor heart rate and QTc during co-therapy. Correct potassium and magnesium abnormalities and consider an alternative antidepressant in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Maprotiline with Octreotide?
MediHelp rates the interaction as moderate. Maprotiline and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and QT prolongation, and maprotiline, a tetracyclic antidepressant, can also prolong the QT interval. Together they may increase the risk of arrhythmia, especially with bradycardia or electrolyte disturbance.
How serious is the interaction between Maprotiline and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor heart rate and QTc during co-therapy. Correct potassium and magnesium abnormalities and consider an alternative antidepressant in patients with other QT risk factors.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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