Drug interactions
Maprotiline + Olanzapine / samidorphan
Severity: Moderate
Maprotiline and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine causes sedation, anticholinergic effects and orthostatic hypotension, all of which maprotiline can add to. Falls, drowsiness and constipation may be more likely.
What this interaction means in plain words
Maprotiline and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, hypotension and anticholinergic effects.
What to do
Monitor for sedation, orthostatic hypotension and anticholinergic effects, and counsel on rising slowly. Reduce doses if these are troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Maprotiline and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine causes sedation, anticholinergic effects and orthostatic hypotension, all of which maprotiline can add to. Falls, drowsiness and constipation may be more likely.
How serious is the interaction between Maprotiline and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and anticholinergic effects, and counsel on rising slowly. Reduce doses if these are troublesome.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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