Drug interactions
Maprotiline + Olanzapine
Severity: Moderate
Maprotiline and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents may modestly prolong the QT interval and both have anticholinergic and sedative effects. Combined use can increase arrhythmia risk and additive CNS and anticholinergic adverse effects. Maprotiline also lowers the seizure threshold.
What this interaction means in plain words
Maprotiline and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and additive anticholinergic, sedative and seizure-threshold-lowering effects.
What to do
Obtain a baseline ECG and recheck after dose changes, and keep potassium and magnesium normal. Monitor for sedation, anticholinergic effects and seizures, and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Maprotiline with Olanzapine?
MediHelp rates the interaction as moderate. Maprotiline and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents may modestly prolong the QT interval and both have anticholinergic and sedative effects. Combined use can increase arrhythmia risk and additive CNS and anticholinergic adverse effects. Maprotiline also lowers the seizure threshold.
How serious is the interaction between Maprotiline and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and recheck after dose changes, and keep potassium and magnesium normal. Monitor for sedation, anticholinergic effects and seizures, and use the lowest effective doses.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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