Drug interactions
Maprotiline + Olodaterol inhaled
Severity: Moderate
Maprotiline and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline can prolong the QT interval, and tricyclic-type antidepressants can potentiate the cardiovascular effects of beta2 agonists such as olodaterol. This may increase the risk of tachycardia and ventricular arrhythmia.
What this interaction means in plain words
Maprotiline and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and pharmacodynamic potentiation of beta2-agonist cardiovascular effects.
What to do
Monitor heart rate, ECG and potassium in patients with cardiac disease or other QT risk factors. Consider alternative therapy if QTc prolongation or arrhythmia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Maprotiline and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline can prolong the QT interval, and tricyclic-type antidepressants can potentiate the cardiovascular effects of beta2 agonists such as olodaterol. This may increase the risk of tachycardia and ventricular arrhythmia.
How serious is the interaction between Maprotiline and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and potassium in patients with cardiac disease or other QT risk factors. Consider alternative therapy if QTc prolongation or arrhythmia occurs.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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