Drug interactions
Maprotiline + Opium tincture
Severity: Moderate
Maprotiline and Opium tincture: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opium tincture contains morphine and other opioids, which depress the central nervous system and respiration. Maprotiline is a sedating tetracyclic antidepressant, so combined use can deepen drowsiness and impair psychomotor performance. Respiratory depression is possible, particularly at higher opioid doses.
What this interaction means in plain words
Maprotiline and Opium tincture can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects from opioid receptor agonism and the antihistaminic and sedative properties of maprotiline.
What to do
Use the lowest effective opioid dose and watch for excessive sedation and slowed breathing, especially when starting or raising doses. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Opium tincture?
MediHelp rates the interaction as moderate. Maprotiline and Opium tincture can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opium tincture contains morphine and other opioids, which depress the central nervous system and respiration. Maprotiline is a sedating tetracyclic antidepressant, so combined use can deepen drowsiness and impair psychomotor performance. Respiratory depression is possible, particularly at higher opioid doses.
How serious is the interaction between Maprotiline and Opium tincture?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective opioid dose and watch for excessive sedation and slowed breathing, especially when starting or raising doses. Counsel patients to avoid driving and alcohol.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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